Patents

Recent Patents from CLIMB and Our Collaborative and Service Project Partners

Issued Patents

Bhargava R, Kenkel SM. Widefield photothermal infrared spectroscopic imaging. U.S. patent application US20240094116A1. Filed 2023 Sep 6. Published 2024 Mar 21. Issued 2026 Feb 1.

Wang L, Nie L, Cai X, Maslov K, Anastasio MA, Huang C, Schoonover RW. Transcranial photoacoustic/thermoacoustic tomography brain imaging informed by adjunct image data. U.S. patent US12408839B2. Issued 2025 Sep 9.

Boppart SA, Sorrells JE, Iyer RR. Digital domain photon peak event detection system and method. U.S. patent US12385837B2. Issued 2025 Aug 12.

Bhargava R, Mittal S. Tissue microenvironment analysis based on tiered classification and clustering analysis of digital pathology images. U.S. patent US12346410B2. Filed 2021 Oct 1. Issued 2025 Jul 1.

Boppart SA, Tu H, You S. Clipping-assisted dual-fluorophore sensing. U.S. patent US12092576B2. Issued 2024 Sep 17.

Anastasio MA, Matthews T, Kelly B. Deep learning-assisted image reconstruction for tomographic imaging. U.S. patent US12039639B2. Issued 2024 Jul 16.

Bhargava R, Chen L. Coated tubular construct for biological and industrial applications and method of making a tubular construct. U.S. patent US12030256B2. Filed 2022 Feb 16. Issued 2024 Jul 9.

Bhargava R, Kenkel SM. Method and apparatus for nanoscale infrared absorption tomography. U.S. patent US11860087B2. Filed 2022 Apr 2. Issued 2024 Jan 2.

Zhu Q, Anastasio MA, Uddin S. Systems and methods of optimizing functional images of a lesion region using guided diffuse optical tomography. U.S. patent US11857289B2. Issued 2024 Jan 2.

Boppart SA, Nguyen FT, Zysk AM. Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors. U.S. patent US11779219B2. Issued 2023 Oct 10.

Phal Y, Yee KL, Bhargava R. Vibrational circular dichroism infrared spectroscopic imaging microscope. U.S. patent US11499910B2. Filed 2021 Jul 15. Issued 2022 Nov 15.

Schnell M, Carney PS, Bhargava R. Infrared-optical hybrid imaging technology for all-digital histopathology. U.S. patent US11493323B2. Filed 2020 Jan 3. Issued 2022 Nov 8.

Boppart SA, Dsouza RI, Spillman DR Jr., Pande P, Monroy GL. Compact briefcase OCT system for point-of-care imaging. U.S. patent US11445915B2. Issued 2022 Sep 20.

Pending Patent Applications

Fitzgerald S, Mahadevan-Jansen A, Boppart SA, Monroy GL, Werkhaven JA. Non-contact clinical Raman spectroscopy guided probe and applications of same. U.S. patent application US20250380871A1. Published 2025 Dec 18. Pending.

Yeh KL, Bhargava R. Mid-infrared optical lens assemblies for confocal laser scanning microscopy. U.S. patent application US20250298228A1. Filed 2025 Mar 17. Published 2025 Sep 25. Pending.

Boppart SA, Sorrells JE, Iyer RR, Yang L. Systems and methods for hyperspectral microscopy. U.S. patent application US20250147294A1. Published 2025 May 8. Pending.

Bhargava R, Falahkheirkhah K, Mukherjee SS. Simulated optical histopathology from hyperspectral chemical imagery. U.S. patent application US20250061693A1. Filed 2024 Aug 15. Published 2025 Feb 20. Pending.

Tehrani KF, De la Cadena A, Boppart SA. Systems and methods for precision nonlinear microscopy. U.S. patent application US20240255424A1. Published 2024 Aug 1. Pending.

Ma H, Liu Y. An Omni-Mesoscope for multiscale high-throughput quantitative phase imaging of cellular dynamics and high-content molecular characterization. U.S. provisional patent application 63/670,569. Filed 2024 Jul 12. Pending.

Boppart SA, Zurauskas M. Multiphase optical coherence microscopy imaging. U.S. patent application US20240061226A1. Published 2024 Feb 22. Pending.

Tehrani KF, Boppart SA. Multiplexed super-resolution label-free nonlinear microscopy. U.S. patent application US20230237618A1. Published 2023 Jul 27. Pending.

Boppart SA, Sorrells J, Iyer RR. Digital domain photon peak event detection system and method. U.S. patent application US20220397530A1. Published 2022 Dec 15. Pending.

Popescu G, Anastasio MA, Hu C, He S, He Y. Complex system for contextual spectrum mask generation based on quantitative imaging. U.S. patent application US20220383986A1. Published 2022 Dec 1. Pending.

Eden JG, Sun PP, Chen W, Nguyen T, Monroy GL, Won J, Boppart SA. Microplasma integrated array otoscope speculum and ear treatment methods. U.S. patent application US20220338722A1. Published 2022 Oct 27. Pending.

Zurauskas M, Boppart SA. Optical phantom and method for characterizing optical imaging systems. U.S. patent application US20220283090A1. Published 2022 Sep 8. Pending.